Monday, December 17, 2007
http://www.sciencedaily.com/videos/health_medicine/prostate_cancer/
Detecting Prostate Cancer Earlier
Cancer Biologists Develop More Accurate Blood Test for Prostate Cancer
September 1, 2005 — A new blood test is more reliable at finding prostate cancer in its early stages by detecting a protein marker in blood plasma. Doctors say the new test, now in clinical trials, will have an accuracy of 95 percent, better than the commonly used PSA, which signals abnormal prostate conditions rather than cancer.
See also:
Health & Medicine
* Prostate Cancer
* Men's Health
* Urology
* Prostate Health
* Diseases and Conditions
* Colon Cancer
Reference
* Urology
* Metastasis
* Embryonic stem cell
* General fitness training
BALTIMORE--Most men over age 50 are familiar with PSA testing, used to detect prostate cancer. But the test can sometimes miss cancer cases. Now a new test can find cancer earlier.
When James Foster discovered he had prostate cancer, his life barely missed a beat. Now a prostate cancer survivor, Foster says, "I don't think I was shocked. I truly was almost preparing for it." But finding out he had the disease wasn't easy or quick. Like many men his age, he experienced the problem of having elevated PSA test results that could mean any number of things.
Robert Getzenberg, a cancer biologist at Johns Hopkins School of Medicine in Baltimore, says, "A blood test of PSA is not really an accurate marker of prostate cancer, but really a marker of abnormal prostate conditions."
Cancer biologists now have a new blood test, currently in clinical trials, that's more reliable and accurate at finding the disease in its earliest stages. The new test identifies a protein marker in blood plasma, called early prostate cancer antigen -- or EPCA. When the marker appears in a blood test, it indicates a high probability of cancer, not just that something is wrong. Doctors say it's the best indicator yet of prostate cancer.
"If you have the EPCA marker in your blood, you almost certainly, higher than 95-percent chance, have prostate cancer," Getzenberg says -- promising new number that might help reduce the amount of prostate biopsies, a painful, invasive procedure to confirm cancer, and focus on men who are truly at risk.
The new blood test is currently in clinical trials, and doctors will be recruiting new patients this fall. For trial information, visit www.tesserainc.com.
show background
BACKGROUND: In the first clinical study of a new blood protein associated with prostate cancer, researchers have found that the marker EPCA, or early prostate cancer antigen, can successfully detect prostate cancer in its earliest stages. The current technique for detecting prostate cancer prostate-specific antigen (PSA) testing, can sometimes indicate cancer when none is there. Prostate cancer is the most common type affecting American men, with about 232,090 new cases diagnosed in 2005.
WHAT IS THE PROSTATE: The prostate is a walnut-sized gland, located between the bladder and the penis and in front of the rectum. Its primary function is the production of seminal fluid, the milky substance that nourishes sperm.
WHAT IS PSA TESTING: PSA testing is one step in early identification of prostate tumors, combined with digital rectal examination. But PSA testing can miss some cancers, or produce a false positive (indicate a cancer that doesn't exist). Furthermore, a prostate biopsy is a very painful and unpleasant procedure, with 12 separate tissue extractions followed by a month of pain. The biopsy usually needs to be repeated each year after the first positive PSA result, even if the initial biopsy comes out negative. Of the 1.8 million biopsies performed annually, only 15 percent come out negative. Reducing the number of biopsies requires for an accurate diagnosis would bring welcome relief to many patients.
NEW BLOOD TEST: Researchers at Johns Hopkins measured the ECPA levels in 46 patients, including those with prostate cancer, bladder, colon and kidney cancer, spinal cord injury, and noncancerous prostate inflammation, as well as 16 healthy individuals. They found that EPCA levels were high in 11 of the 12 prostate cancer patients and low in all the healthy individuals. They estimate an accurate diagnosis rate of 94 percent. When coupled with standard PSA screening, the new blood test could help reduce the number of unnecessary biopsies and undetected prostate tumors. The ECPA test very specific to prostate cancer; it doesn't indicate other types of cancer or benign prostate conditions.
WHEN AVAILABLE: Larger clinical trials will be starting soon, and it is believed that the blood test will be generally available to medical practitioners in 2006.
Note: This story and accompanying video were originally produced for the American Institute of Physics series Discoveries and Breakthroughs in Science by Ivanhoe Broadcast News and are protected by copyright law. All rights reserved.
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Prostate Cancer
Learn about different treatment options. Get more info online now.
www.trelstar.com
Prostate Cancer Treatment
Comprehensive Prostate Cancer Info Find Latest Treatment Options
TreatmentProstateCancer.Net
Prostate Cancer
Top 5 Websites For Prostate Cancer
www.FasterZone.com
Prostate Cancer Treatment
Holistic Recipe reduced PSA 100% + My expierence with Formal Treatment
www.dangoldstone.com
The Amas® Test -
The antibody test for cancer; Prostate, breast and other cancers.
www.oncolabinc.com
Related Stories
PSA Level Predicts Future Prostate Growth (February 15, 2000) — The higher a man's prostate specific antigen (PSA) level is, the more likely his prostate will continue to grow abnormally, researchers at UT Southwestern Medical Center at Dallas report. ... > read more
Annual Prostate Cancer Screening Test Appears To Save Lives (October 24, 2005) — Men who have a yearly blood test to examine their prostate specific antigen levels are nearly three times less likely to die from prostate cancer than those who don't have annual screenings, ... > read more
New Test For Early Detection Of Prostate Cancer Shows Promise (May 16, 2005) — In the first clinical study of a new blood protein associated with prostate cancer, researchers have found that the marker, called EPCA or early prostate cancer antigen, can successfully detect ... > read more
Research Offers New Tool In Fight Against Prostate Cancer (May 6, 1998) — Research from the University of Michigan Comprehensive Cancer Center strongly suggests that PSA tests can reliably gauge the effectiveness of chemotherapy for advanced prostate cancer. ... > read more
Novel Prostate Cancer Marker May Lead To Earlier Diagnosis And Fewer Repeat Bioposies (March 12, 2004) — Findings published in this month's issue of the Journal of Urology indicate that prostate cancer could be detected as many as five years earlier than it is currently being diagnosed by testing ... >
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Top 6 Websites For Prostate Cancer
www.FasterPicks.com
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Learn the Symptoms and Treatment options for Prostate Cancer.
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Detecting Prostate Cancer Earlier
Cancer Biologists Develop More Accurate Blood Test for Prostate Cancer
September 1, 2005 — A new blood test is more reliable at finding prostate cancer in its early stages by detecting a protein marker in blood plasma. Doctors say the new test, now in clinical trials, will have an accuracy of 95 percent, better than the commonly used PSA, which signals abnormal prostate conditions rather than cancer.
See also:
Health & Medicine
* Prostate Cancer
* Men's Health
* Urology
* Prostate Health
* Diseases and Conditions
* Colon Cancer
Reference
* Urology
* Metastasis
* Embryonic stem cell
* General fitness training
BALTIMORE--Most men over age 50 are familiar with PSA testing, used to detect prostate cancer. But the test can sometimes miss cancer cases. Now a new test can find cancer earlier.
When James Foster discovered he had prostate cancer, his life barely missed a beat. Now a prostate cancer survivor, Foster says, "I don't think I was shocked. I truly was almost preparing for it." But finding out he had the disease wasn't easy or quick. Like many men his age, he experienced the problem of having elevated PSA test results that could mean any number of things.
Robert Getzenberg, a cancer biologist at Johns Hopkins School of Medicine in Baltimore, says, "A blood test of PSA is not really an accurate marker of prostate cancer, but really a marker of abnormal prostate conditions."
Cancer biologists now have a new blood test, currently in clinical trials, that's more reliable and accurate at finding the disease in its earliest stages. The new test identifies a protein marker in blood plasma, called early prostate cancer antigen -- or EPCA. When the marker appears in a blood test, it indicates a high probability of cancer, not just that something is wrong. Doctors say it's the best indicator yet of prostate cancer.
"If you have the EPCA marker in your blood, you almost certainly, higher than 95-percent chance, have prostate cancer," Getzenberg says -- promising new number that might help reduce the amount of prostate biopsies, a painful, invasive procedure to confirm cancer, and focus on men who are truly at risk.
The new blood test is currently in clinical trials, and doctors will be recruiting new patients this fall. For trial information, visit www.tesserainc.com.
show background
BACKGROUND: In the first clinical study of a new blood protein associated with prostate cancer, researchers have found that the marker EPCA, or early prostate cancer antigen, can successfully detect prostate cancer in its earliest stages. The current technique for detecting prostate cancer prostate-specific antigen (PSA) testing, can sometimes indicate cancer when none is there. Prostate cancer is the most common type affecting American men, with about 232,090 new cases diagnosed in 2005.
WHAT IS THE PROSTATE: The prostate is a walnut-sized gland, located between the bladder and the penis and in front of the rectum. Its primary function is the production of seminal fluid, the milky substance that nourishes sperm.
WHAT IS PSA TESTING: PSA testing is one step in early identification of prostate tumors, combined with digital rectal examination. But PSA testing can miss some cancers, or produce a false positive (indicate a cancer that doesn't exist). Furthermore, a prostate biopsy is a very painful and unpleasant procedure, with 12 separate tissue extractions followed by a month of pain. The biopsy usually needs to be repeated each year after the first positive PSA result, even if the initial biopsy comes out negative. Of the 1.8 million biopsies performed annually, only 15 percent come out negative. Reducing the number of biopsies requires for an accurate diagnosis would bring welcome relief to many patients.
NEW BLOOD TEST: Researchers at Johns Hopkins measured the ECPA levels in 46 patients, including those with prostate cancer, bladder, colon and kidney cancer, spinal cord injury, and noncancerous prostate inflammation, as well as 16 healthy individuals. They found that EPCA levels were high in 11 of the 12 prostate cancer patients and low in all the healthy individuals. They estimate an accurate diagnosis rate of 94 percent. When coupled with standard PSA screening, the new blood test could help reduce the number of unnecessary biopsies and undetected prostate tumors. The ECPA test very specific to prostate cancer; it doesn't indicate other types of cancer or benign prostate conditions.
WHEN AVAILABLE: Larger clinical trials will be starting soon, and it is believed that the blood test will be generally available to medical practitioners in 2006.
Note: This story and accompanying video were originally produced for the American Institute of Physics series Discoveries and Breakthroughs in Science by Ivanhoe Broadcast News and are protected by copyright law. All rights reserved.
Ads by Google
Advertise here
Prostate Cancer
Learn about different treatment options. Get more info online now.
www.trelstar.com
Prostate Cancer Treatment
Comprehensive Prostate Cancer Info Find Latest Treatment Options
TreatmentProstateCancer.Net
Prostate Cancer
Top 5 Websites For Prostate Cancer
www.FasterZone.com
Prostate Cancer Treatment
Holistic Recipe reduced PSA 100% + My expierence with Formal Treatment
www.dangoldstone.com
The Amas® Test -
The antibody test for cancer; Prostate, breast and other cancers.
www.oncolabinc.com
Related Stories
PSA Level Predicts Future Prostate Growth (February 15, 2000) — The higher a man's prostate specific antigen (PSA) level is, the more likely his prostate will continue to grow abnormally, researchers at UT Southwestern Medical Center at Dallas report. ... > read more
Annual Prostate Cancer Screening Test Appears To Save Lives (October 24, 2005) — Men who have a yearly blood test to examine their prostate specific antigen levels are nearly three times less likely to die from prostate cancer than those who don't have annual screenings, ... > read more
New Test For Early Detection Of Prostate Cancer Shows Promise (May 16, 2005) — In the first clinical study of a new blood protein associated with prostate cancer, researchers have found that the marker, called EPCA or early prostate cancer antigen, can successfully detect ... > read more
Research Offers New Tool In Fight Against Prostate Cancer (May 6, 1998) — Research from the University of Michigan Comprehensive Cancer Center strongly suggests that PSA tests can reliably gauge the effectiveness of chemotherapy for advanced prostate cancer. ... > read more
Novel Prostate Cancer Marker May Lead To Earlier Diagnosis And Fewer Repeat Bioposies (March 12, 2004) — Findings published in this month's issue of the Journal of Urology indicate that prostate cancer could be detected as many as five years earlier than it is currently being diagnosed by testing ... >
Prostate Cancer Testing
Access to Answers, Info & Forums On Prostate Cancer Health & More.
RevolutionHealth.com
Prostate Cancer
Top 6 Websites For Prostate Cancer
www.FasterPicks.com
Prostate Cancer Info
Learn the Symptoms and Treatment options for Prostate Cancer.
www.ProstateAnswers.com
Thursday, December 6, 2007
Science News
Engineers Developing New Cements To Heal Spinal Fractures
ScienceDaily (Oct. 30, 2007) — New research could offer hope for victims of the most devastating spinal injuries - typically those caused in car crashes.
See also:
Health & Medicine
* Bone and Spine
* Osteoporosis
* Leukemia
Matter & Energy
* Civil Engineering
* Materials Science
* Engineering
Reference
* Bone fracture
* Orthopedic surgery
* Human skeleton
* Scoliosis
Biological cements to repair 'burst fractures' of the spine are being developed and tested in a major new collaborative project between the University of Leeds and Queen's University Belfast. The team will be working to develop and examine the effects of novel cement materials for the treatment of burst fractures.
Bone cements, similar to those used in joint replacement surgery, are already being used to strengthen damaged vertebrae of patients with diseases such as osteoporosis, in a procedure known as vertebroplasty, but 'burst fractures' to the spine, injuries often sustained in major impact accidents and falls, are much more difficult to treat. They account for over 1,000 emergency NHS admissions each year and often require highly complex, invasive surgery and a long stay in hospital.
"This type of fracture causes the vertebra to burst apart and in severe cases fragments of bone can be pushed into the spinal cord," says Dr Ruth Wilcox of Leeds' Institute of Medical and Biological Engineering. "Surgeons may be able to join bone fragments together and stabilize the spine with the use of metal screws and rods, but patients with these injuries are often in a really bad way, so the less invasive the treatment, the better."
The project team at Queen's has expertise in developing and testing synthetic biomaterials for the repair of bone defects. "These materials can be delivered to the fracture site by injection and mimic the chemical composition of bone itself," says Dr Fraser Buchanan, from the University's School of Mechanical and Aerospace Engineering.
At Leeds the team has expertise in computational modelling of the spine and will be able to provide Queen's with data to assist in the development of novel biomaterials and to simulate how they will perform in patients.
Statistically, burst fractures are seen more in younger people, and not enough is currently known about the long term consequences of using existing cements for the treatment of this type of injury. There is evidence to show that some patients with osteoporosis, who tend to be older, can develop fractures in the vertebrae adjacent to those treated with vertebroplasty.
"We think this may be because current cements are stiffer than the bone itself causing an imbalance in the way the spine bears weight. This may increase loading on the neighbouring vertebrae, which can lead to further damage" says Dr Wilcox.
"Clearly we need to develop biomaterials that more closely match the properties of real bone. This project offers the perfect opportunity to use the range of complimentary skills of this grouping to predict the effects of newly developed cements and even incorporate biological agents to assist the body's own healing process," added Dr Buchanan.
To be able to use bone cements for burst fractures would be a major leap forward. It would be simpler, quicker and much less invasive for the patient, reducing both recovery times and NHS costs.
Funding is being provided by the Engineering and Physical Sciences Research Council.
Adapted from materials provided by University of Leeds.
Need to cite this story in your essay, paper, or report? Use one of the following formats:
APA
MLA
University of Leeds (2007, October 30). Engineers Developing New Cements To Heal Spinal Fractures. ScienceDaily. Retrieved December 6, 2007, from http://www.sciencedaily.com /releases/2007/10/071029081517.htm
Engineer Dr. Ruth Wilcox, University of Leeds. (Credit: Simon & Simon photography)
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GreatHealthResource.info/Osteoporos
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Millions have already taken this amazing test. What's your RealAge?
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Reverse Bone Loss
Megadoses of calcium are NOT the answer - Special Report
www.hsibaltimore.com/Osteoporosis
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Innovative Bone Substitutes and Combined Technologies.
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Find Info & Facts On Spine Surgery. Info- Spine Surgery Here.
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Liquid Cement Can Stop The Pain And Prevent Deformity From Osteoporosis Of The Spine (Apr. 4, 2000) — The pain and disfigurement of osteoporosis of the spine may be prevented with the help of a liquid bone cement, according to new findings being presented by University of Maryland Medical Center ... > read more
Seat Belt Injuries Could Signal More Serious Trauma In Children (Aug. 10, 2007) — Ill-fitting seatbelts raise the risk of serious injury to children involved in car accidents. And seat belt injuries should alert physicians to look for signs of more serious consequences, ... > read more
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Vertebroplasty Improves Back Pain, Activity Level, Mayo Clinic Study Reports (Dec. 30, 2005) — A Mayo Clinic study has found patients report less back pain at rest and while active following vertebroplasty, a procedure in which medical cement is injected into painful compression fractures in ... > read more
Study Shows Calcitonin-Salmon Nasal Spray Helps Prevent New Spinal Fractures In Women With Existing Osteoporosis (Sep. 16, 1998) — A recently completed study shows that calcitonin-salmon nasal spray reduced by 36 percent the incidence of new spinal fractures in postmenopausal women with osteoporosis. ... > read more
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ScienceDaily (Oct. 30, 2007) — New research could offer hope for victims of the most devastating spinal injuries - typically those caused in car crashes.
See also:
Health & Medicine
* Bone and Spine
* Osteoporosis
* Leukemia
Matter & Energy
* Civil Engineering
* Materials Science
* Engineering
Reference
* Bone fracture
* Orthopedic surgery
* Human skeleton
* Scoliosis
Biological cements to repair 'burst fractures' of the spine are being developed and tested in a major new collaborative project between the University of Leeds and Queen's University Belfast. The team will be working to develop and examine the effects of novel cement materials for the treatment of burst fractures.
Bone cements, similar to those used in joint replacement surgery, are already being used to strengthen damaged vertebrae of patients with diseases such as osteoporosis, in a procedure known as vertebroplasty, but 'burst fractures' to the spine, injuries often sustained in major impact accidents and falls, are much more difficult to treat. They account for over 1,000 emergency NHS admissions each year and often require highly complex, invasive surgery and a long stay in hospital.
"This type of fracture causes the vertebra to burst apart and in severe cases fragments of bone can be pushed into the spinal cord," says Dr Ruth Wilcox of Leeds' Institute of Medical and Biological Engineering. "Surgeons may be able to join bone fragments together and stabilize the spine with the use of metal screws and rods, but patients with these injuries are often in a really bad way, so the less invasive the treatment, the better."
The project team at Queen's has expertise in developing and testing synthetic biomaterials for the repair of bone defects. "These materials can be delivered to the fracture site by injection and mimic the chemical composition of bone itself," says Dr Fraser Buchanan, from the University's School of Mechanical and Aerospace Engineering.
At Leeds the team has expertise in computational modelling of the spine and will be able to provide Queen's with data to assist in the development of novel biomaterials and to simulate how they will perform in patients.
Statistically, burst fractures are seen more in younger people, and not enough is currently known about the long term consequences of using existing cements for the treatment of this type of injury. There is evidence to show that some patients with osteoporosis, who tend to be older, can develop fractures in the vertebrae adjacent to those treated with vertebroplasty.
"We think this may be because current cements are stiffer than the bone itself causing an imbalance in the way the spine bears weight. This may increase loading on the neighbouring vertebrae, which can lead to further damage" says Dr Wilcox.
"Clearly we need to develop biomaterials that more closely match the properties of real bone. This project offers the perfect opportunity to use the range of complimentary skills of this grouping to predict the effects of newly developed cements and even incorporate biological agents to assist the body's own healing process," added Dr Buchanan.
To be able to use bone cements for burst fractures would be a major leap forward. It would be simpler, quicker and much less invasive for the patient, reducing both recovery times and NHS costs.
Funding is being provided by the Engineering and Physical Sciences Research Council.
Adapted from materials provided by University of Leeds.
Need to cite this story in your essay, paper, or report? Use one of the following formats:
APA
MLA
University of Leeds (2007, October 30). Engineers Developing New Cements To Heal Spinal Fractures. ScienceDaily. Retrieved December 6, 2007, from http://www.sciencedaily.com /releases/2007/10/071029081517.htm
Engineer Dr. Ruth Wilcox, University of Leeds. (Credit: Simon & Simon photography)
Ads by Google
Advertise here
Osteoporosis
Get Symptoms & Treatment Options. Find the Dangers of Osteoporosis.
GreatHealthResource.info/Osteoporos
Prepare to be Shocked
Millions have already taken this amazing test. What's your RealAge?
www.RealAge.com
Reverse Bone Loss
Megadoses of calcium are NOT the answer - Special Report
www.hsibaltimore.com/Osteoporosis
Bone Substitutes
Innovative Bone Substitutes and Combined Technologies.
www.graftys.com
Spine Surgery
Find Info & Facts On Spine Surgery. Info- Spine Surgery Here.
www.YourSpineSurgery.net
Related Stories
Liquid Cement Can Stop The Pain And Prevent Deformity From Osteoporosis Of The Spine (Apr. 4, 2000) — The pain and disfigurement of osteoporosis of the spine may be prevented with the help of a liquid bone cement, according to new findings being presented by University of Maryland Medical Center ... > read more
Seat Belt Injuries Could Signal More Serious Trauma In Children (Aug. 10, 2007) — Ill-fitting seatbelts raise the risk of serious injury to children involved in car accidents. And seat belt injuries should alert physicians to look for signs of more serious consequences, ... > read more
New Pain Relief Treatment For Spinal Compression Fractures Related To Osteoporosis Available At Mayo Clinic (Aug. 12, 1999) — People who have prolonged and debilitating pain associated with compression fractures in their spinal vertebrae may be able to find relief with a procedure now being offered at Mayo Clinic. ... > read more
Vertebroplasty Improves Back Pain, Activity Level, Mayo Clinic Study Reports (Dec. 30, 2005) — A Mayo Clinic study has found patients report less back pain at rest and while active following vertebroplasty, a procedure in which medical cement is injected into painful compression fractures in ... > read more
Study Shows Calcitonin-Salmon Nasal Spray Helps Prevent New Spinal Fractures In Women With Existing Osteoporosis (Sep. 16, 1998) — A recently completed study shows that calcitonin-salmon nasal spray reduced by 36 percent the incidence of new spinal fractures in postmenopausal women with osteoporosis. ... > read more
Search ScienceDaily
Number of stories in archives: 44,032
Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily's archives for related news topics,
the latest news stories, reference articles, science videos, images, and books.
Ads by Google
Advertise here
Osteoporosis Treatment
Ancient Chinese Bone Formula Helps Restore Healthy Bones
osteoking.com
Bone Density Osteoporosis
Breaking News, Expert Tips, Member Support, Treatment Options & More
www.EverydayHealth.com
Osteoporosis Spine
Learn About Osteoporosis Treatments Find Osteoporosis Spine.
www.OsteoporosisTreatment.biz
Just In:
Smell You Later
Reprogrammed Adult Cells Treat Sickle-cell Anemia
Hinode Mission Delves Into Solar Mysteries
New Plant-derived Cancer Medicines
Hinode Mission Delves Into Solar Mysteries
Science Video News
Spinal Cord Injuries: Back on Your Feet
Paraplegic patients who still have some active nerve endings in their legs can find major improvements with a new therapy. During rehabilitation on a. ... > full story
* EMG Helps Physiatrists Find Causes of Pain
* Pediatric Neurologists Use MRI to Understand How Strokes Impair Verbal Abilities
* Orthotics and Prosthetics Experts Use New Materials to Let Injured Athletes Play
* more science videos
Breaking News
... from NewsDaily.com
* Transfusion-free medicine an option
* Breast cancer MRI may alter treatment plan
* UPI NewsTrack Health and Science News
* U.S. child cancer rates down significantly
* $200 million given to telescope project
* more science news
In Other News ...
* U.S. Senate passes AMT patch
* Man convicted in fatal synagogue shooting
* Arizona to offer 'enhanced' licenses
* Poll: Dems OK with presidential choices
* Sex offender charged in boy's killing
* Senate panel postpones contempt votes
* Defense bill loses gay hate-crime language
* AMT patch stalled in U.S. Senate
* more world news
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